© 2016 NeuroRx, Inc.

*This drug is investigational and not approved by the US FDA

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Combination Treatment

 

Scientific rationale supports the approach of combining an NMDA antagonist, such as D-cycloserine, with additional therapeutic targets in the treatment of Acute Suicidal Ideation/Behavior (ASIB) in Bipolar Depression. This is crucial due to the fact that despite the substantial promise shown by D-cycloserine in the treatment of depression and schizophrenia, the treatment must be administered with an antipsychotic to counteract side effects.

 

5-HT2a Receptor Antagonist

One key potential combination target that has shown promise in counteracting the side effects of

D-cycloserine is the 5-HT2a receptor, a G protein-coupled receptor and a member of the serotonin family.  It is known for its role in mediating certain antipsychotic drugs. Studies have demonstrated that deceased suicidal and other depressed patients have had more 5-HT2a receptors than normal patients, indicating that the increased presence of 5-HT2a receptors may play a role in depression.

 

Lurasidone (Latuda®), a 5-HT2a antagonist, is currently marketed as a tier three antipsychotic and is occasionally used in bipolar depression. However, in animal akathisia studies, it was discovered that lurasidone and other 5-HT2a antagonists have an unexpected synergistic effect with D-cycloserine, potentially enhancing the antidepressant effect while minimizing the potential psychomimetic side effects.

 

The synergistic effects of NMDA and 5-HT2a antagonists in the rat akathisia model are described in detail in several US and ex-US patent filings.  The combination of lurasidone (and other 5HT2a antagonists) and D-cycloserine led to a significant reduction in akathisia compared to control and to lurasidone alone.  akathisia is defined as a state of agitation, distress, and restlessness that is an occasional side-effect of antipsychotic and antidepressant drugs.

 

Ketamine

The inclusion of ketamine, an FDA-approved anesthetic, in a combination treatment for acute suicidal crisis in bipolar depression is also supported by scientific research. Like D-cycloserine, ketamine works by targeting the NMDA receptor.  Clinical research has demonstrated that by blocking the NMDA channel, ketamine has a nearly immediate effect on reversing depression and suicidality in people with bipolar disorder.

 

Despite these promising clinical findings, ketamine is not FDA-approved for the treatment of bipolar depression.  Ketamine's anti-depressant and anti-suicidal activity is short-lived. Treatment of acute suicidality in bipolar patients would therefore require repeat infusions of ketamine. However, ketamine administration is associated with hallucinations and other psychomimetic side effects, and could require 1-2 weekly visits of the patient to a treatment center.

 

A sequential treatment approach that can leverage the immediate anti-suicidal benefit of ketamine, while limiting the drug to a single, initial dose, has the potential to offer acutely suicidal bipolar patients a much needed therapeutic option. NeuroRx believes that an induction of ketamine, followed by a fixed-dose combination of D-cycloserine and  lurasidone  could offer an oral, outpatient therapy. This fixed-dose combination is the basis of our NRX-101 investigational drug, has the potential to significantly extend ketamine’s anti-suicidal / anti-depressant benefits and offer an improved side effect profile.

 

 

 

 

 

NeuroRx is pursuing a strategic combination treatment approach

based on scientific rationale that supports pairing an NMDA antagonist with

additional therapeutic targets in the treatment of Acute Suicidal Ideation/Behavior (ASIB) in Bipolar Depression.