JONATHAN C. JAVITT, M.D., M.P.H.
Chief Executive Officer
Dr. Javitt has played leadership roles in seven successful healthcare IT and biopharma startups with public exits. He has additionally led drug-development engagements for Merck, Allergan, Pharmacia, Novartis, and Pfizer. He was appointed to healthcare leadership roles under Presidents Reagan, George H.W. Bush, Clinton, and George W. Bush. In the latter role he was commissioned to lead the White House policy for universal adoption of Health IT and establishment of the Office of the National Coordinator. He is a graduate of Princeton University, Cornell University Medical College, Harvard School of Public Health, the Wills Eye Hospital, and Johns Hopkins Medical School. Dr. Javitt has published more than 200 scientific works in the areas of health outcomes and pharmacoeconomics that have been cited by more than 16,000 people.
ROBERT BESTHOF, M.I.M.
Chief Commercial Officer
Mr. Besthof is a global biopharmaceutical executive with a 25+year career covering global pipeline & country operational marketing & sales roles. He has managed numerous specialty diseases areas, including small as well as billion dollar brands in Ophthalmology, Neuroscience, Pain, Pulmonary Vascular Disease, etc. His teams have played key roles in translating new science into investable commercial paths, reshaping markets, launching breakthrough products, and closing numerous licensing deals. Mr. Besthof has worked for Eli Lilly, Wyeth, and most recently Pfizer, as Vice President Commercial Development Neuroscience & Pain. Earlier in his career he worked for Deutsche Bank and for various consulting firms. He holds a B.A. from Case Western Reserve University and a Masters in Int’l Management from the Thunderbird School of Global Management.
RICHARD C. SIEGEL, PH.D.
Dr. Siegel brings extensive expertise in both technical and strategic aspects of early and late stage drug development. His experience includes process development and manufacture of small molecule drugs, monoclonal antibodies, therapeutic proteins and conjugates, peptides, cellular products and oligonucleotides. During his career, Dr. Siegel has held a number of high-level drug development and manufacturer positions within the Johnson & Johnson family of companies. These include Vice President of R&D and Global Head of Portfolio Management at Janssen Research and Development.
BRIAN J. DEL BUONO, PH.D., J.D.
Chief Legal Officer
Brian has over 30 years of multinational scientific and legal experience in FDA-regulated pharmaceuticals and biologics, with an emphasis on both branded and generic FDA-regulated products, intellectual property, regulatory affairs, strategic business development, mergers and acquisitions, corporate governance and corporate transactions including licensing. He also has substantial experience in biotech/pharma R&D innovation and management, and has had key responsibilities in large merger integration efforts. Prior to joining NeuroRx, Brian was VP/Chief Legal & Regulatory Officer for Stuart Therapeutics, Sr. VP/Chief Legal Officer & Corporate Secretary for The Sun Products Corporation, and was a partner at Sterne, Kessler, Goldstein & Fox, PLLC. Before entering into his legal practice, Brian spent nearly 10 years in academic and corporate biopharma R&D, most recently with Becton Dickinson & Co. Brian holds a J.D., cum laude, from Georgetown University Law Center, an M.S. and a Ph.D. in Microbiology/Biochemistry from The Pennsylvania State University, and was a postdoctoral fellow in Biochemistry and Hematology/Oncology at Boston University School of Medicine.
MARTIN BRECHER, M.D., MBA
Head of Clinical Development
Dr. Brecher joins NeuroRx with over 30 years of experience in the pharmaceutical industry. He has held senior leadership positions in global clinical development in large and small biopharmaceutical firms and clinical research organizations, including Astra Zeneca, Johnson & Johnson, SK Life Sciences, Hoechst Marion Roussell (now Sanofi), PPD, etc.; earlier in his career he was a medical officer in the division neuropharmacological products of the FDA. Dr. Brecher has been involved in the development and approvals of numerous drugs, including the various indications for Seroquel (e.g. bipolar depression), Risperdal, etc.
Dr. Brecher graduated with a Bachelor of Science from MIT, and received his medical degree and trained as a psychiatrist at SUNY Medical School in Brooklyn, NY. He has held academic appointments at SUNY, and Baylor College of Medicine. He also received an MBA from the Wharton School of Management, at the University of Pennsylvania. He has over 30 peer-reviewed publications. Dr. Brecher continues to practice psychopharmacology.
PHILIP T. LAVIN, PH.D.
Dr. Lavin is a highly-respected biostatistician with more than 30 years of experience supporting the design and analysis of clinical trials. Previously, he was a member of the biostatistics faculty at the Harvard School of Public Health and a member of the Department of Surgery at Harvard Medical School where he was affiliated for over 25 years. He co-founded Boston Biostatistics in 1983, a company now known as Aptiv Solutions. During his career, Dr. Lavin has served as lead biostatistician for 50 FDA approvals, including 38 PMAs, more to date than any other biostatistician. He has also served as a Special Government Employee for 30 years where he has advised FDA on complex statistical and policy issues.
JAMES H. BRANDON, C.P.A.
Comptroller & Acting CFO
James H. Brandon, CPA, has practiced as a Maryland licensed Certified Public Accountant for over 35 years. Mr. Brandon has been a partner in several firms, sold a practice to American Express, was the managing member of a Caribbean island resort, and is currently a sole practitioner serving the Washington DC. Metropolitan area. His clients span the country and he currently has business and individual clients in over 25 states.
Mr. Brandon's area of concentration is business and individual accounting and taxation. Mr. Brandon is well versed in accounting systems and has conducted seminars in the use of certain software. Mr. Brandon was the auditor of several local governments in Maryland. Mr. Brandon also prepares probate court accounting for personal representatives. Mr. Brandon is also a court-appointed bankruptcy CPA.
Mr. Brandon is a member of
DENNIS K. MCBRIDE, PH.D.
Chief Strategy Officer & Senior Scientist
Dr. McBride has led numerous national and international initiatives in neuroscience and its interface with information technology, national security, and medical technology/drug development within the federal government, three of which are now multi-billion dollar enterprises. He began his career as a medical scientist in Naval Aviation and ergonomics and served in eight nationally-prominent laboratories and headquarters organizations, including the Defense Advanced Research Projects Agency (DARPA), Naval Aerospace Medical Research Lab, Naval Research Lab, the Office of Naval Research, and the Naval Medical Research Institute. Upon retiring as a highly decorated senior officer (O-6), he assumed the leadership of the Potomac Institute for Policy Studies, which he continues to serve as President Emeritus. Following his ten year term, he was recruited back to the National Defense University to lead the Center for Technology and National Security Policy, culminating his government career there as Senior Executive-4 (Civilian equivalent to Rear Admiral/Vice Admiral).
Dennis has served as adviser to Cabinet Secretaries, congressional committees, and to major corporate C-Suite executives. His educational background includes formal enrollment at the University of Georgia, Naval Aerospace Medical Institute (Flight Surgeon School), the University of Southern California, the London School of Economics, and Harvard Business School, with award of the Ph.D. in experimental psychology, four master’s degrees, and additional postdoctoral education in aviation medicine, systems engineering science, and strategic disruption. He has published widely, was elected by faculty in 1999 to full professor, and has served at multiple universities, full- and part-time in colleges of Arts & Sciences, Engineering, Public Policy, and Medicine. For the past 12 years, Dr. McBride has served as adjunct Professor at Georgetown University School of Medicine and co-Director of Georgetown’s Regulatory Science Program.
Regulatory & Patient Advocacy Advisor
Mr. Pines previously served as Associate Commissioner of the US Food and Drug Administration.
Melvin L. Morganroth, MD
Clinical Advisor - COVID-19
Dr. Morganroth received both his undergraduate degree and medical degree from the University of Michigan in Ann Arbor. He completing both his internship and residency in Internal Medicine at Yale University School of Medicine. He completed a Pulmonary and Critical Care Fellowship at the University of Colorado Health Sciences Center in Denver. He was an Assistant Professor at the University of Michigan in the Pulmonary and Critical Care Division from 1984-1990. At the University of Michigan, in addition to being active in patient care, he was also director of the Critical Care Medicine Unit, co-director of the critical care fellowship training program and carried out basic research on acute lung injury. Since 1990 he has been the director of the research department in the Pulmonary, Critical Care and Sleep Division of The Oregon Clinic. He is active in patient care, teaching and clinical research. He has been the principal investigator in many research studies and authored multiple journal articles and book chapters on topics related to respiratory disease.
Harry B. Peled, MD FACC, CCS, CCS-P, HEC-C
Clinical Advisor - COVID-19
Dr. Harry Peled is the Medical director of Cardiology and Critical Care at Saint Jude medical center in Fullerton, California. In addition to being board-certified in cardiology and critical care he is also board-certified in geriatrics,palliative care and Neurocritical care. He graduated from Albert Einstein College of Medicine with special distinction for research. He has authored work published In the New England Journal of Medicine, Chest, Annals of internal medicine, and many others. He also holds a masters in bio ethics and health policy from Loyola University.